PLoS One. 2009 Jan; 49(1):6-8. 1996 Sep; 50(3):656-61. 2004 Jan; 2(1):9-13. Prolonged infusion of angiotensin II into normal rats induces stellate cell activation and proinflammatory events in liver. 2012 May 22; 109(21):E1369-76. Adv Second Messenger Phosphoprotein Res. 2011 Apr; 25(2):305-17. J Biol Chem. 2005 Jun 10; 280(23):21763-72. 1994 Jun 21; 91(13):6030-4. Hepatology. Proc Natl Acad Sci U S A. Hepatology. Nishiura T, Nishimura T, deSerres S, Godfrey V, Bradham CA, Nakagawa T. Role of Kupffer cells and gut-derived endotoxins in alcoholic liver injury. 1998 Nov; 18(11):6353-64. Schnabl B, Choi YH, Olsen JC, Hagedorn CH. Transplantation. Bradham CA, Schemmer P, Stachlewitz RF, Thurman RG. 2018 09; 68(3):918-932. Regulatory elements in the 5'-flanking region and the first intron contribute to transcriptional control of the mouse alpha 1 type I collagen gene. 2010 Mar; 51(3):942-52. Different mechanisms decrease hepatic collagen and albumin production in fasted rats. 1999 Mar; 31(2):173-9. 2015 Jan; 22(1):164-73. Non-alcoholic steatohepatitis-induced fibrosis: Toll-like receptors, reactive oxygen species and Jun N-terminal kinase. Gastroenterology. 5' stem-loop of collagen alpha 1(I) mRNA inhibits translation in vitro but is required for triple helical collagen synthesis in vivo. Hepatology. Nat Rev Gastroenterol Hepatol. Meurer SK, Alsamman M, Sahin H, Wasmuth HE. Rusyn I, Bradham CA, Cohn L, Schoonhoven R, Swenberg JA. Estrogen increases sensitivity of hepatic Kupffer cells to endotoxin. 1997 Nov; 113(5):1589-98. Lemasters JJ, Nieminen AL, Qian T, Trost LC, Elmore SP, Nishimura Y, Crowe RA, Cascio WE, Bradham CA. 2019 Feb; 3(2):180-192. 2009 Jan; 130(1):16-26. 2008 Feb; 47(2):677-85. Previous liver regeneration induces fibro-protective mechanisms during thioacetamide-induced chronic liver injury. 2011 Apr; 25(4):1133-44. TLR4 enhances TGF-beta signaling and hepatic fibrosis. Floch MH, Walker WA, Sanders ME, Nieuwdorp M, Kim AS. Inhibition of nuclear factor kappaB and phosphatidylinositol 3-kinase/Akt is essential for massive hepatocyte apoptosis induced by tumor necrosis factor alpha in mice. PLoS One. Wastewater sequencing reveals early cryptic SARS-CoV-2 variant transmission. Antifibrotic effects of a tissue inhibitor of metalloproteinase-1 antibody on established liver fibrosis in rats. PNAS Nexus. medRxiv. The gut-liver axis and the intersection with the microbiome. 2001 Jul 10; 104(2):221-6. 2000 Apr 21; 275(16):12207-13. 2018 06; 67(6):2150-2166. Hepatology. Schrum LW, Bird MA, Salcher O, Burchardt ER, Grisham JW. Proc Natl Acad Sci U S A. Free cholesterol-loaded macrophages are an abundant source of tumor necrosis factor-alpha and interleukin-6: model of NF-kappaB- and map kinase-dependent inflammation in advanced atherosclerosis. J Biol Chem. Am J Physiol Gastrointest Liver Physiol. Ikejima K, Enomoto N, Seabra V, Ikejima A. Gene regulation in hepatic stellate cell. Toll-like receptor 2 and palmitic acid cooperatively contribute to the development of nonalcoholic steatohepatitis through inflammasome activation in mice. Reversibility of Liver Fibrosis and Inactivation of Fibrogenic Myofibroblasts. Awareness, treatment, and control of vascular risk factors among stroke survivors. Characterization of the interaction between alphaCP(2) and the 3'-untranslated region of collagen alpha1(I) mRNA. The Crosstalk between Hepatocytes, Hepatic Macrophages, and Hepatic Stellate Cells Facilitates Alcoholic Liver Disease. Loomba R, Seguritan V, Li W, Long T, Klitgord N, Bhatt A, Dulai PS, Caussy C. YIPF6 controls sorting of FGF21 into COPII vesicles and promotes obesity. The fecal microbiome of ALS patients. Yata Y, Scanga A, Gillan A, Yang L, Reif S, Breindl M. Liver fibrosis: signals leading to the amplification of the fibrogenic hepatic stellate cell. Jobin C, Panja A, Hellerbrand C, Iimuro Y, Didonato J. Confocal microscopy of the mitochondrial permeability transition in necrotic cell killing, apoptosis and autophagy. Nonalcoholic fatty liver disease with cirrhosis increases familial risk for advanced fibrosis. Oncogenic Ras activates c-Jun via a separate pathway from the activation of extracellular signal-regulated kinases. J Clin Invest. 2018 09; 68(3):1070-1086. Pericytes and perivascular fibroblasts are the primary source of collagen-producing cells in obstructive fibrosis of the kidney. Multiplex short tandem repeat profiling of immortalized hepatic stellate cell line Col-GFP HSC. 1989 May; 9(5):2224-7. Gastroenterology. Mallat A, Praux AM, Serradeil-Le Gal C, Raufaste D, Gallois C. Differential regulation of hepatocyte DNA synthesis by cAMP in vitro in vivo. Hydrogen peroxide-induced liver cell necrosis is dependent on AP-1 activation. 2022 07; 10(7):e1953. J Clin Invest. 2021; 16(12):e0260721. WebBrenners wife, Jill Silverman Brenner, M.D., is a primary care internist and rheumatologist. 2020 02 13; 5(3). Clin Gastroenterol Hepatol. Sancho-Bru P, Bataller R, Colmenero J, Gasull X, Moreno M, Arroyo V. Bone marrow-derived fibrocytes participate in pathogenesis of liver fibrosis. Cell Metab. Stroke. To see the data as text. Am J Physiol. Development of a new, simple rat model of early alcohol-induced liver injury based on sensitization of Kupffer cells. 2015 Feb; 21(2):159-65. PLoS One. Deficiency of NOX1 or NOX4 Prevents Liver Inflammation and Fibrosis in Mice through Inhibition of Hepatic Stellate Cell Activation. J Surg Res. Researchers can. DNA Cell Biol. Mitochondrial dysfunction in the pathogenesis of necrotic and apoptotic cell death. 2005 May; 41(5):1046-55. University of California San Diego named John M. Carethers as the vice chancellor for Health Sciences (VCHS), effective January 1, 2023. 2001 Dec; 281(6):G1357-68. J Biol Chem. 2009; 44 Suppl 19:1-7. Proc Natl Acad Sci U S A. 2022 Mar; 1(1):pgac006. Semin Liver Dis. 2003 Oct; 125(4):1009. Yan AW, Fouts DE, Brandl J, St?rkel P, Torralba M, Schott E. Role and cellular source of nicotinamide adenine dinucleotide phosphate oxidase in hepatic fibrosis. J Clin Invest. Autocrine expression of activated transforming growth factor-beta(1) induces apoptosis in normal rat liver. 2022 Oct 28; 11(11). J Mol Med (Berl). Signal transduction during liver regeneration. Link between gut-microbiome derived metabolite and shared gene-effects with hepatic steatosis and fibrosis in NAFLD. 2014 Aug; 124(8):3566-78. Interleukin-6 increases rat metalloproteinase-13 gene expression through stimulation of activator protein 1 transcription factor in cultured fibroblasts. Reif S, Lang A, Lindquist JN, Yata Y, Gabele E, Scanga A. TRAIL-mediated apoptosis requires NF-kappaB inhibition and the mitochondrial permeability transition in human hepatoma cells. 2006 May; 130(6):1562. 1989 May; 8(4):279-85. 2000 Jun 01; 95(11):3568-77. J Biol Chem. 2011 Mar 11; 286(10):8609-8619. 2001 Jan; 33(1):81-90. Front Physiol. Hepatology. Pharmacological inhibition of P2RX7 ameliorates liver injury by reducing inflammation and fibrosis. Caussy C, Hsu C, Singh S, Bassirian S, Kolar J, Faulkner C, Sinha N, Bettencourt R, Gara N, Valasek MA, Schnabl B. Involvement of death receptor-related signaling pathways. DNA. Nicotinamide adenine dinucleotide phosphate oxidase in experimental liver fibrosis: GKT137831 as a novel potential therapeutic agent. J Biol Chem. Harada N, Hatano E, Koizumi N, Nitta T, Yoshida M, Yamamoto N. c-Jun N-terminal kinase mediates hepatic injury after rat liver transplantation. The role of gut-derived bacterial toxins and free radicals in alcohol-induced liver injury. Inhibition of both extracellular signal-regulated kinase and c-Jun kinase and upregulation of endothelin B receptors. 2019 07; 70(1):127-141. 2010 Jul-Aug; 19(4):311-20. Paik YH, Lee KS, Lee HJ, Yang KM, Lee SJ, Lee DK, Han KH, Chon CY, Lee SI, Moon YM. 2009 Sep; 1(8-9):513-24. Blood. 1996 Feb; 23(2):379-80. Cancer Res. DNA Cell Biol. Hepatic porphyrias. Hepatology. 2020 May 05; 56(5). Uehara T, Bennett B, Sakata ST, Satoh Y, Bilter GK, Westwick JK. 2011 Apr; 300(4):G516-25. Parsons CJ, Bradford BU, Pan CQ, Cheung E, Schauer M, Knorr A, Krebs B, Kraft S, Zahn S, Brocks B, Feirt N, Mei B, Cho MS. From quiescence to activation: Gene regulation in hepatic stellate cells. Tumor necrosis factor alpha-induced interleukin-8 production via NF-kappaB and phosphatidylinositol 3-kinase/Akt pathways inhibits cell apoptosis in human hepatocytes. Immunosuppression, hepatitis B virus variants: Synergistic role in hepatic fibrogenesis. Roles of AKT and sphingosine kinase in the antiapoptotic effects of bile duct ligation in mouse liver. Iimuro Y, Bradford BU, Yamashina S, Rusyn I, Nakagami M, Enomoto N, Kono H, Frey W, Forman D. The 5' stem-loop regulates expression of collagen alpha1(I) mRNA in mouse fibroblasts cultured in a three-dimensional matrix. Curr Pathobiol Rep. 2014 Dec; 2(4):171-183. Verna EC, Patel J, Bettencourt R, Nguyen P, Hernandez C, Valasek MA, Kisselva T. Aging and liver disease. J Biol Chem. Int Psychogeriatr. 2004 Jun; 135(6):619-28. 2015 Dec; 149(7):1784-93. The origin of myofibroblasts in liver fibrosis. Int J Mol Sci. 2017 03; 15(3):463-464. 2013 Apr; 20(4):649-58. 2003 Jan 10; 278(2):927-33. Modulation of constitutive collagen gene expression by lipid peroxidation. 2008 Apr 15; 5(3):338-42. Mol Genet Genomic Med. Bacterial translocation and changes in the intestinal microbiome in mouse models of liver disease. A liver full of JNK: signaling in regulation of cell function and disease pathogenesis, and clinical approaches. Hepatol Commun. Alcohol Clin Exp Res. Hepatology. Reactive oxygen species delay control of lymphocytic choriomeningitis virus. 2007 Nov; 46(5):1443-52. Nat Commun. 1995 Jul; 22(1):241-51. Karthikeyan S, Levy JI, De Hoff P, Humphrey G, Birmingham A, Jepsen K. MiR-690 treatment causes decreased fibrosis and steatosis and restores specific Kupffer cell functions in NASH. Korean J Hepatol. Hepatology. 1999 Aug; 31(4):305-19. Alcohol, intestinal bacterial growth, intestinal permeability to endotoxin, and medical consequences: summary of a symposium. Am J Pathol. 2016 Feb 10; 19(2):227-39. J Biol Chem. The role of p70S6K in hepatic stellate cell collagen gene expression and cell proliferation. The mitochondrial permeability transition augments Fas-induced apoptosis in mouse hepatocytes. The Role of NADPH Oxidases (NOXs) in Liver Fibrosis and the Activation of Myofibroblasts. Cell Host Microbe. 1988 Sep-Oct; 8(5):1040-5. Antioxid Redox Signal. Xu Y, Bialik S, Jones BE, Iimuro Y, Kitsis RN, Srinivasan A. Porphyrias. Effects of three superoxide dismutase genes delivered with an adenovirus on graft function after transplantation of fatty livers in the rat. Hepatology. Science. A dual reporter gene transgenic mouse demonstrates heterogeneity in hepatic fibrogenic cell populations. 2012 Nov; 67(11):1357-64. NADPH oxidase signal transduces angiotensin II in hepatic stellate cells and is critical in hepatic fibrosis. 2016; 7:47. Kodama Y, Taura K, Miura K, Schnabl B, Osawa Y. Molecular pathogenesis of liver fibrosis. Gao B, Emami A, Zhou R, Lang S, Duan Y, Wang Y, Jiang L. Targeting the Wnt signaling pathway through R-spondin 3 identifies an anti-fibrosis treatment strategy for multiple organs. 2002 Sep; 132(3):441-9. Semaphorin 7A contributes to TGF--mediated liver fibrogenesis. Int J Biochem Cell Biol. Replicative senescence of activated human hepatic stellate cells is accompanied by a pronounced inflammatory but less fibrogenic phenotype. PLoS One. Biochim Biophys Acta. 1990 Feb; 10(2):689-95. Hepatology. Am J Clin Nutr. 2022 08 02; 34(8):1201-1213.e5. Am J Physiol. 1995; 255:342-59. Association between serum interleukin-6 concentrations and mortality in older adults: the Rancho Bernardo study. DNA-mediated gene transfer into adult rat hepatocytes in primary culture. Krempen K, Grotkopp D, Hall K, Bache A, Gillan A, Rippe RA. 2010; 2010:362847. Brenner edited blockbuster hits including 2012, Independence Day and Born On The Fourth Of July, for which he won his Oscar in 1990. Hepatology. Liver Int. Hepatology. Transient induction of c-jun during hepatic regeneration. Decaris ML, Li KW, Emson CL, Gatmaitan M, Liu S, Wang Y, Nyangau E, Colangelo M, Angel TE, Beysen C, Cui J, Hernandez C, Lazaro L. Magnetic Resonance Elastography vs Transient Elastography in Detection of Fibrosis and Noninvasive Measurement of Steatosis in Patients With Biopsy-Proven Nonalcoholic Fatty Liver Disease. Exp Biol Med (Maywood). Lin A, Frost J, Deng T, Smeal T, al-Alawi N, Kikkawa U, Hunter T. NF-I/Sp1 switch elements regulate collagen alpha 1(I) gene expression. Bradham CA, Qian T, Streetz K, Trautwein C. NF-kappaB inactivation converts a hepatocyte cell line TNF-alpha response from proliferation to apoptosis. 1998 Aug; 115(2):443-51. Neurology. 2020 12; 72(6):2182-2196. Caussy C, Bhargava M, Villesen IF, Gudmann NS, Leeming DJ, Karsdal MA, Faulkner C, Bao D, Liu A, Lo MT, Bettencourt R, Bassirian S. The Role of Fibrosis and Liver-Associated Fibroblasts in the Pathogenesis of Hepatocellular Carcinoma. Cell Death Differ. Leadership - Institute for Diabetes and Metabolic Health - UC San Cellular and molecular biology of hepatocyte growth, regeneration and gene expression. Am J Physiol Gastrointest Liver Physiol. Fibrocyte-like cells recruited to the spleen support innate and adaptive immune responses to acute injury or infection. 1994 Dec 09; 269(49):30789-97. 1993 Feb; 17(2):287-92. 1989 Feb 16; 337(6208):661-3. Study of factors causing excess protoporphyrin accumulation in cultured skin fibroblasts from patients with protoporphyria. Int J Stroke. Traditional Chinese Medicine Fuzheng Huayu Prevents Development of Liver Fibrosis in Mice. Neurobiol Aging. Gastroenterology. Hepatology. Nishio T, Koyama Y, Fuji H, Ishizuka K, Iwaisako K, Taura K, Hatano E. Collagenolysis-dependent DDR1 signalling dictates pancreatic cancer outcome. Gastroenterology. Joint statement on missions and submissions of papers to AGA journals. His career has been replete with accomplishments in research, clinical work and administration, and at UCSD he is still able to round on patients, J Neurol. Stroke. TRAM2 protein interacts with endoplasmic reticulum Ca2+ pump Serca2b and is necessary for collagen type I synthesis. CD40 activates NF-kappa B and c-Jun N-terminal kinase and enhances chemokine secretion on activated human hepatic stellate cells. Novel association between serum pentraxin-2 levels and advanced fibrosis in well-characterised patients with non-alcoholic fatty liver disease. Cloning of murine ferrochelatase. Proc Natl Acad Sci U S A. Uehara T, Xi Peng X, Bennett B, Satoh Y, Friedman G, Currin R. In vivo pattern of lipopolysaccharide and anti-CD3-induced NF-kappa B activation using a novel gene-targeted enhanced GFP reporter gene mouse. Hepatology. Hepatology. After being discharged, he attended Temple University, where he majored in mass communication and graduated with honors. Brenner was a writer, director or producer of 115 television documentaries and headed the documentary units of Westinghouse Broadcasting and Metromedia, winning nearly 30 awards including an Emmy, before moving to comedy. 1998 Feb 15; 101(4):802-11. Hepatology. Alcohol Clin Exp Res. Inherited human cPLA(2alpha) deficiency is associated with impaired eicosanoid biosynthesis, small intestinal ulceration, and platelet dysfunction. 2000 Mar; 15 Suppl:D20-5. Toll-like receptor 9 promotes steatohepatitis by induction of interleukin-1beta in mice. 1998 04; 274(4):G669-76. 2010 Feb 25; 3:39-47. Ludin A, Itkin T, Gur-Cohen S, Mildner A, Shezen E, Golan K, Kollet O, Kalinkovich A, Porat Z, D'Uva G, Schajnovitz A, Voronov E. The single nucleotide polymorphism CRTh2 rs533116 is associated with allergic asthma and increased expression of CRTh2. Inhibition of prolyl hydroxylases increases hepatic insulin and decreases glucagon sensitivity by an HIF-2a-dependent mechanism. 2006 Jul; 131(1):272-5. 1991 Jun; 87(6):2230-5. Proc Am Thorac Soc. Curr Pathobiol Rep. 2016 Mar; 4(1):27-35. Mixed-methods quantitative-qualitative study of 29 nonagenarians and centenarians in rural Southern Italy: focus on positive psychological traits. 2005 Apr 08; 280(14):13374-82. Identification of Novel Fibrosis Modifiers by InVivo siRNA Silencing. See more options in the Advanced Search tab. J Hepatol. J Clin Exp Hepatol. 1992 Jul-Aug; 11(6):443-52. Enomoto N, Seabra V, ikejima A. gene regulation in hepatic fibrogenic cell populations toll-like 9. 95 ( 11 ):3568-77 280 ( 23 ):21763-72 permeability to endotoxin, medical... Missions and submissions of papers to AGA journals ):221-6 Italy: on... Production via NF-kappaB and phosphatidylinositol 3-kinase/Akt is essential for massive hepatocyte apoptosis by... 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