View abstract. Ophthalmologica 2017;237(3):159-66. Gale, C. R., Hall, N. F., Phillips, D. I., and Martyn, C. N. Lutein and zeaxanthin status and risk of age-related macular degeneration. Associations between antioxidant and zinc intake and the 5-year incidence of early age-related maculopathy in the Beaver Dam Eye Study. Med Hypotheses 1983;12:239-51. View abstract. Goltz, S. R., Campbell, W. W., Chitchumroonchokchai, C., Failla, M. L., and Ferruzzi, M. G. Meal triacylglycerol profile modulates postprandial absorption of carotenoids in humans. It is thought to function as a light filter, protecting the eye tissues from sunlight damage. Coyne, T., Ibiebele, T. I., Baade, P. D., Dobson, A., McClintock, C., Dunn, S., Leonard, D., and Shaw, J. Diabetes mellitus and serum carotenoids: findings of a population-based study in Queensland, Australia. Xiong K, Zhao Y, Hu S, Ma A, Ma Y. Dose-response relationship between oral lutein intake and plasma lutein concentration: A randomized controlled trial. Nicknamed the eye vitamin, lutein is a type of carotenoid antioxidant that is most well-known for protecting eye health. Lutein improves visual function in some patients with retinal degeneration: a pilot study via the Internet. 1999;70(2):247-251. Dietary lutein and zeaxanthin are associated with working memory in an older population. Lutein /zeaxanthin for the treatment of age-related cataract: AREDS2 randomized trial report no. Read Next: Top 7 Ways Carrot & Carrot Juice Benefit Your Body. View abstract. Gale, C. R., Hall, N. F., Phillips, D. I., and Martyn, C. N. Plasma antioxidant vitamins and carotenoids and age-related cataract. 2-15-2007;458(2):128-135. Naylor CD, O'Rourke K, Detsky AS, Baker JP. Some observational studies show that xanthophyll carotenoids, including lutein, can help reduce the risk of developing heart disease and stroke. Seddon JM, Ajani UA, Sperduto R, et al. View abstract. A meta-analysis. 2006;84(5):971-974. No information from medical studies supports the use of this product for any other health problem. View abstract. Ma, L., Yan, S. F., Huang, Y. M., Lu, X. R., Qian, F., Pang, H. L., Xu, X. R., Zou, Z. Y., Dong, P. C., Xiao, X., Wang, X., Sun, T. T., Dou, H. L., and Lin, X. M. Effect of lutein and zeaxanthin on macular pigment and visual function in patients with early age-related macular degeneration. Although its best to get enough of this antioxidant naturally through a healthy diet high in anti-inflammatory foods, nutritional supplements or fortified foods and beverages can also be used by some people in order to help increase levels. Taking lutein, A serious intestinal disease in premature infants (, An inherited eye condition that causes poor. Yagi, A., Fujimoto, K., Michihiro, K., Goh, B., Tsi, D., and Nagai, H. The effect of lutein supplementation on visual fatigue: a psychophysiological analysis. Positive effects of lutein and zeaxanthin supplementation and topical application of these carotenoids have been shown to be beneficial for the skin. Xu J, Song C, Song X, Zhang X, Li X. Carotenoids and risk of fracture: a meta-analysis of observational studies. Clinical trial of lutein in patients with retinitis pigmentosa receiving vitamin A. Arch.Ophthalmol. A., Kardinaal, A. F., Van, Poppel G., and Van, Norren D. Lens aging in relation to nutritional determinants and possible risk factors for age-related cataract. Berendschot, T. T., Goldbohm, R. A., Klopping, W. A., van de, Kraats J., van Norel, J., and van Norren, D. Influence of lutein supplementation on macular pigment, assessed with two objective techniques. Chew EY, Clemons TE, Agrn E, et al. Effect of the main dietary antioxidants (carotenoids, gamma-tocopherol, polyphenols, and vitamin C) on alpha-tocopherol absorption. Modification of lymphocyte DNA damage by carotenoid supplementation in postmenopausal women. The average person who eats the standard American diet is likely running low in this carotenoid, in addition to other important antioxidants. Amount of fat in the diet affects bioavailability of lutein esters but not of alpha-carotene, beta-carotene, and vitamin E in humans. View abstract. Kostic D, White WS, Olson JA. Moeller, S. M., Voland, R., Tinker, L., Blodi, B. Korobelnik JF, Rougier MB, Delyfer MN, et al. Am.J Clin.Nutr 1996;64(4):594-602. Neuroepidemiology. View abstract. Association between dietary carotenoid intakes and the risk of asthma in adults: a cross-sectional study of NHANES, 2007-2012. Nutrients 2022;14(4):872. 8-15-2012;92(10):2043-2049. Ann Neurol. Piermarocchi, S., Saviano, S., Parisi, V., Tedeschi, M., Panozzo, G., Scarpa, G., Boschi, G., and Lo, Giudice G. Carotenoids in Age-related Maculopathy Italian Study (CARMIS): two-year results of a randomized study. 2006;90(7):927-928. Its possible that for some people, even with a relatively high intake of high-antioxidantfoods, their blood levels might be high enough in nutrients like lutein, but testing tissues within their eyes will show that their retinal levels still remain too low. In addition to being found within thepigments of oureyes, carotenoids are also present within the skin. Plant foods and colon cancer: an assessment of specific foods and their related nutrients (United States). J Am Optom Assoc 1999;70:39-47. Reboul E, Thap S, Perrot E, et al. View abstract. Handelman, G. J., Nightingale, Z. D., Lichtenstein, A. H., Schaefer, E. J., and Blumberg, J. Loughman J, Loskutova E, Butler JS, Siah WF, O'Brien C. Macular pigment response to lutein, zeaxanthin, and meso-zeaxanthin supplementation in open-angle glaucoma: A randomized controlled trial. View abstract. Effect of lutein supplementation on visual function in nonproliferative diabetic retinopathy. Ophthalmology 2008;115(5):876-883. View abstract. Both older and younger people should consume plenty of lutein in order to reduce the risk of oxidative damage that can lead to disorders down the road. Sommerburg O, Keunen JE, Bird AC, van Kuijk FJ. Incidence of cataract operations in Finnish male smokers unaffected by alpha tocopherol or beta carotene supplements. Similarly, other studies show that higher dietary intakes ofzeaxanthin and lutein along with other natural antioxidants, includingvitamin C,beta-caroteneandvitamin E, are associated with a significantly decreased risk of cataract formation. View abstract. WebMD does not provide medical advice, diagnosis or treatment. 2007;125(9):1225-1232. Design: Subjects were 1290 mother-child pairs in an ongoing cohort study. View abstract. View abstract. Bartlett, H., Howells, O., and Eperjesi, F. The role of macular pigment assessment in clinical practice: a review. Invest Ophthalmol.Vis.Sci. Int J Sport Nutr Exerc Metab 2005;15:401-12. Knekt P, Ritz J, Pereira MA, et al. The human body cannot synthesize lutein or zeaxanthin on its own, which means we must obtain these important nutrients from our diets (or, in some cases, supplements). View abstract. Skin Pharmacol.Physiol 2007;20(4):199-210. Dietary modification of human macular pigment density. Lyle BJ, Mares-Perlman JA, Klein BE, et al. Schunemann HJ, Grant BJ, Freudenheim JL, et al. Online ahead of print. 3-1-2001;153(5):424-432. Bernstein PS, Li B, Vachali PP, Gorusupudi A, Shyam R, Henriksen BS, Nolan JM. Bahrami, H., Melia, M., and Dagnelie, G. Lutein supplementation in retinitis pigmentosa: PC-based vision assessment in a randomized double-masked placebo-controlled clinical trial [NCT00029289]. View abstract. View abstract. Chasan-Taber L, Willett WC, Seddon JM, et al. Ito, Y., Wakai, K., Suzuki, K., Ozasa, K., Watanabe, Y., Seki, N., Ando, M., Nishino, Y., Kondo, T., Ohno, Y., and Tamakoshi, A. View abstract. BMC Pregnancy Childbirth 2022;22(1):427. View abstract. View abstract. View abstract. View abstract. View abstract. Goodman GE, Schaffer S, Omenn GS, et al. View abstract. View abstract. J Nutr 2002;132:3668-73. View abstract. Ophthalmology 2002;109:2272-8.. View abstract. Nutr Neurosci 2021. Zhang W, Li W, Du J. Antioxidant intake and risk of incident age-related nuclear cataracts in the Beaver Dam Eye Study. Heinrich, U., Gartner, C., Wiebusch, M., Eichler, O., Sies, H., Tronnier, H., and Stahl, W. Supplementation with beta-carotene or a similar amount of mixed carotenoids protects humans from UV-induced erythema. Retina 2008;28(1):103-110. Br J Ophthalmol 1998;82:907-10. View abstract. Relation between dietary intake, serum concentrations, and retinal concentrations of lutein and zeaxanthin in adults in a Midwest population. That said, possible lutein and zeaxanthin side effects can include harmless yellowingof the skin calledcarotenemia and an upset stomach/vomiting if you take too much. Background: Low intakes of dietary antioxidants may contribute to increases in asthma and allergy. Lutein and zeaxanthin supplementation in preterm very low-birth-weight neonates in neonatal intensive care units: a multicenter randomized controlled trial. Br J Nutr 2021;126(7):1028-1039. View abstract. Roodenburg AJ, Leenen R, van het Hof KH, et al. 2007;61(9):1121-1127. View abstract. It's related to beta-carotene and vitamin A. Lutein-rich foods include egg yolks, broccoli, spinach, kale, corn, orange pepper, kiwi fruit, grapes, orange juice, zucchini and squash. Can.J.Ophthalmol. Just one drop of this thick cream will moisturize dry hands or itchy eczema spots. Am.J.Clin.Nutr. 2012;90(5):e399-e403. Nutrients. A prospective study of carotenoid intake and risk of cataract extraction in US men. Cancer Epidemiol.Biomarkers Prev. View abstract. View abstract. Cangemi, F. E. TOZAL Study: an open case control study of an oral antioxidant and omega-3 supplement for dry AMD. View abstract. Hozawa, A., Jacobs, D. R., Jr., Steffes, M. W., Gross, M. D., Steffen, L. M., and Lee, D. H. Relationships of circulating carotenoid concentrations with several markers of inflammation, oxidative stress, and endothelial dysfunction: the Coronary Artery Risk Development in Young Adults (CARDIA)/Young Adult Longitudinal Trends in Antioxidants (YALTA) study. Eur.J.Clin.Nutr. Am J Clin Nutr 2012;96(2):356-373. Effects of Lutein/Zeaxanthin Supplementation on the Cognitive Function of Community Dwelling Older Adults: A Randomized, Double-Masked, Placebo-Controlled Trial. View abstract. J Aging Res 2019;2019:3709402. 2013;91(1):6-11. A., Fisher, A. I., Klein, R., Palta, M., Block, G., Millen, A. E., and Wright, J. D. Lutein and zeaxanthin in the diet and serum and their relation to age-related maculopathy in the third national health and nutrition examination survey. pii: E426. Plasma and macular responses to lutein supplement in subjects with and without age-related maculopathy: a pilot study. Plasma carotenoids and vitamin C concentrations and risk of urothelial cell carcinoma in the European Prospective Investigation into Cancer and Nutrition. J Nutr 2004;134:2387-94. View abstract. Connolly, E. E., Beatty, S., Loughman, J., Howard, A. N., Louw, M. S., and Nolan, J. M. Supplementation with all three macular carotenoids: response, stability, and safety. Studies done by the University of Southern California suggest that low levels of lutein within the blood might contribute to the thickening of artery walls. View abstract. Invest Ophthalmol Vis Sci 1997;38:1795-801.. View abstract. A., and Guymer, R. H. Dietary antioxidants and primary prevention of age related macular degeneration: systematic review and meta-analysis. View abstract. Vorgerd M, Grehl T, Jager M, et al. Skinmed. View abstract. It is certified by the National Eczema Association, meaning it is safe for those with eczema or sensitive skina testament to its mildness. 5 Reasons to Add Lamb Meat to Your Diet, St. Johns Wort Benefits for Depression, PMS & Menopause. View abstract. Changes in plasma amino acid patterns in chronic alcoholic patients during ethanol withdrawal syndrome: their clinical implications. Influence of increased fruit and vegetable intake on plasma and lipoprotein carotenoids and LDL oxidation in smokers and nonsmokers. Goodman, M. T., Kiviat, N., McDuffie, K., Hankin, J. H., Hernandez, B., Wilkens, L. R., Franke, A., Kuypers, J., Kolonel, L. N., Nakamura, J., Ing, G., Branch, B., Bertram, C. C., Kamemoto, L., Sharma, S., and Killeen, J. Just like many other types of antioxidants, it is found in brightly colored foods like fruits and vegetables especially leafy greens and types that are deep orange or yellow. Epidemiology. View abstract. Estimates show that more than 25 million people worldwide are affected by age-related macular degeneration or cataracts, especially people aged 55 and older living in industrialized Western nations. Kawabata, F. and Tsuji, T. Effects of dietary supplementation with a combination of fish oil, bilberry extract, and lutein on subjective symptoms of asthenopia in humans. 2002;132(6):1299-1306. Adackapara, C. A., Sunness, J. S., Dibernardo, C. W., Melia, B. M., and Dagnelie, G. Prevalence of cystoid macular edema and stability in oct retinal thickness in eyes with retinitis pigmentosa during a 48-week lutein trial. Dagnelie G, Zorge IS, McDonald TM. Arch Ophthalmol 1993;111:104-9.. View abstract. All rights reserved. Dietary carotenoid intake and risk of developing preeclampsia: a hospital-based case-control study. . 2013;98(3):778-86. For people with a genetic predisposition to eye disorders or cancer, taking more lutein might be necessary. Ophthalmology 2001;108(11):1992-1998. View abstract. View abstract. Arch.Ophthalmol. A., Snodderly, D. M., Klein, M. L., Wooten, B. R., and Chappell, R. Macular pigment density and age-related maculopathy in the Carotenoids in Age-Related Eye Disease Study. Capeding, R., Gepanayao, C. P., Calimon, N., Lebumfacil, J., Davis, A. M., Stouffer, N., and Harris, B. J. Lutein-fortified infant formula fed to healthy term infants: evaluation of growth effects and safety. J Nutr.Biochem. According to the American Macular Degeneration Association, the following foods are the best sources of luteinfor increasing your intake naturally (not to mention for getting other antioxidants, vitamins and minerals too): Lutein andzeaxanthin foods are important maculardegeneration vitamins. J Nutr 2006;136(5):1161-1165. van der Horst-Graat JM, Kok, F. J., and Schouten, E. G. Plasma carotenoid concentrations in relation to acute respiratory infections in elderly people. The effects of lutein on cardiometabolic health across the life course: a systematic review and meta-analysis. Baltimore, MD: Williams & Wilkins, 1995. Yeum KJ, Ahn SH, Rupp de Paiva SA, et al. Zinc is an important mineral that plays a key role in skin health (17). Creatine therapy in myophosphorylase deficiency (McArdle disease): a placebo-controlled crossover trial. Diabetes Care 2004;27:362-6. View abstract. Saxena, S., Srivastava, P., and Khanna, V. K. Antioxidant supplementation improves platelet membrane fluidity in idiopathic retinal periphlebitis (Eales' disease). Zuniga KE, Bishop NJ, Turner AS. View abstract. Br J Nutr 2001;85(2):227-238. Taylor, A., Jacques, P. F., Chylack, L. T., Jr., Hankinson, S. E., Khu, P. M., Rogers, G., Friend, J., Tung, W., Wolfe, J. K., Padhye, N., and Willett, W. C. Long-term intake of vitamins and carotenoids and odds of early age-related cortical and posterior subcapsular lens opacities. View abstract. Eliassen, A. H., Hendrickson, S. J., Brinton, L. A., Buring, J. E., Campos, H., Dai, Q., Dorgan, J. F., Franke, A. View abstract. This can increase their risk for developing deficiencies and experiencing disorders as they age. View abstract. View abstract. View abstract. Traditionally lutein is characterized by its blue light filtering and anti-oxidant properties. San Giovanni, J. P., Chew, E. Y., Clemons, T. E., Ferris, F. L., III, Gensler, G., Lindblad, A. S., Milton, R. C., Seddon, J. M., and Sperduto, R. D. The relationship of dietary carotenoid and vitamin A, E, and C intake with age-related macular degeneration in a case-control study: AREDS Report No. Brown L, Rimm EB, Seddon JM, et al. Ophthalmic Res. Schalch, W., Cohn, W., Barker, F. M., Kopcke, W., Mellerio, J., Bird, A. C., Robson, A. G., Fitzke, F. F., and van Kuijk, F. J. Xanthophyll accumulation in the human retina during supplementation with lutein or zeaxanthin - the LUXEA (LUtein Xanthophyll Eye Accumulation) study. 2015 Aug 25;314(8):791-801. Dietary lutein reduces ultraviolet radiation-induced inflammation and immunosuppression. However, most studies show that benefits are greatest when someone consumes 10 milligrams of lutein per day or more (along with about two milligrams of zeaxanthin perday). The association of plasma micronutrients with the risk of cervical dysplasia in Hawaii. View abstract. Am J Clin Nutr 2016;103(2):481-94. 12-19-2012;104(24):1905-1916. View abstract. J Matern Fetal Neonatal Med 2020:1-6. View abstract. Influence of feeding different vegetables on plasma levels of carotenoids, folate and vitamin C. Effect of disruption of the vegetable matrix. Machida N, Kosehira M, Kitaichi N. Clinical effects of dietary supplementation of lutein with high bio-accessibility on macular pigment optical density and contrast sensitivity: A randomized double-blind placebo-controlled parallel-group comparison trial. View abstract. WebLutein, zeaxanthin, lycopene, and astaxanthin belong to a group of nutrients called carotenoids. Fitzgerald KC, O'Reilly J, Fondell E, et al. 2000;9(3):257-263. Ravindran, R. D., Vashist, P., Gupta, S. K., Young, I. S., Maraini, G., Camparini, M., Jayanthi, R., John, N., Fitzpatrick, K. E., Chakravarthy, U., Ravilla, T. D., and Fletcher, A. E. Inverse association of vitamin C with cataract in older people in India. The ARIC Study Investigators. Int J Food Sci Nutr 2016;67(7):744-53. Smart Grocery Shopping When You Have Diabetes, Surprising Things You Didn't Know About Dogs and Cats, Bird Flu Deaths Prompt U.S. to Test Vaccine in Poultry, COVID Treatment in Development Appears Promising, Marriage May Help Keep Your Blood Sugar in Check, Getting Outdoors Might Help You Take Fewer Meds, New Book: Take Control of Your Heart Disease Risk, Getting Help for a Loved One With Psychosis: It's Complicated, Health News and Information, Delivered to Your Inbox, Amyotrophic lateral sclerosis (ALS, Lou Gehrig's disease), Wet Age-Related Macular Degeneration and Vision Loss, An eye disease that leads to vision loss in older adults (age-related macular degeneration or AMD). J Sci Food Agric. Lutein, zeaxanthin and meso-zeaxanthin supplementation associated with macular pigment optical density. Am.J.Clin.Nutr. Together they can help to preserve vision by protecting the eyes from oxidative stress and UV light damage. View abstract. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. Aleman, T. S., Duncan, J. L., Bieber, M. L., De Castro, E., Marks, D. A., Gardner, L. M., Steinberg, J. D., Cideciyan, A. V., Maguire, M. G., and Jacobson, S. G. Macular pigment and lutein supplementation in retinitis pigmentosa and Usher syndrome. Calories 9.6 kcal Protein 0.51 g Fat 0.75 g Carbohydrate 0.24 g Sodium 00.012 g Lutein 18.0 mg Zeaxanthin 3.6 mg -cryptoxanthin 28.8 g -carotene 1080 g -carotene 270 g Lycopene 2.1 mg Bilberry extract 30.0 mg Blackcurrant extract 72.0 mg DHA 50.9 mg Vitamin B1 0.9 mg Am.J.Clin.Nutr. Arch Ophthalmol 1993;111:761-72. Rubin, L. P., Chan, G. M., Barrett-Reis, B. M., Fulton, A. Bloomer RJ, Fry A, Schilling B, Chiu L, et al. Associations of serum carotenoids with risk of cardiovascular mortality among individuals with type 2 diabetes: Results from NHANES. 2012;96(5):1223S-1233S. Front Nutr 2022;9:924997. Snodderly DM. Am J Clin Nutr 1999;70:517-24. View abstract. View abstract. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version. View abstract. Am J Perinatol. View abstract. Dorgan, J. F., Boakye, N. A., Fears, T. R., Schleicher, R. L., Helsel, W., Anderson, C., Robinson, J., Guin, J. D., Lessin, S., Ratnasinghe, L. D., and Tangrea, J. Cancer Causes Control 2003;14(7):645-655. View abstract. J Invest Dermatol 2004;122:510-7. Prostaglandins Other Lipid Mediat 2022;164:106691. Vitamin A and carotenoids and the risk of Parkinson's disease: a systematic review and meta-analysis. Nolan JM, Power R, Howard AN, et al. Lung cancer mortality and serum levels of carotenoids, retinol, tocopherols, and folic acid in men and women: a case-control study nested in the JACC Study. If you suspect you might benefit from high doses of lutein, its best to speak with your doctor to rule out any potential contraindications. Liew SH, Gilbert CE Spector TD Mellerio J Van Kuijk FJ Beatty S Fitzke F Marshall J Hammond CJ. Foods Slattery ML, Potter JD, Coates A, et al. WebOverview. Invest Ophthalmol.Vis.Sci. View abstract. Acta Ophthalmol Scand 1997;75:634-40. A. Types of Lutein Supplements and Tips for Taking Them: Want to increase your intake of this beneficial antioxidant? Zinc. 2013;14(3):1911-8. Age-Related Eye Disease Study 2 Research Group. Ge XX, Xing MY, Yu LF, et al. Exp.Eye Res. J.Matern.Fetal Neonatal Med. Am J Hypertens. Am J Clin Nutr 2004;80:1508-20. J.Nutr. Lutein and its relative zeaxanthin are pigments called carotenoids. 2009;41(9):1752-1760. View abstract. Int.J.Cancer 9-1-2012;131(5):1158-1168. View abstract. Eur.J.Clin.Nutr. View abstract. View abstract. Exp Eye Res 1997;65:57-62. Invest Ophthalmol Vis Sci 1995;36:276-88. Vegetables, fruit, and cancer. Breast Cancer Res.Treat. Correlation between carotenoid concentrations in serum and normal breast adipose tissue of women with benign breast tumor or breast cancer. View abstract. View abstract. Thurmann PA, Schalch W, Aebischer JC, et al. B., Hansen, R. M., Ashmeade, T. L., Oliver, J. S., Mackey, A. D., Dimmit, R. A., Hartmann, E. E., and Adamkin, D. H. Effect of carotenoid supplementation on plasma carotenoids, inflammation and visual development in preterm infants. View abstract. A., Liu, C., Tang, G., Krinsky, N. I., and Russell, R. M. Human plasma carotenoid response to the ingestion of controlled diets high in fruits and vegetables. OTHER NAME(S): All-E-Lutein, Beta,epsilon-carotene-3,3'-diol, E-L. Lutein is found in many foods, including egg yolks, spinach, kale, corn, orange pepper, kiwi fruit, grapes, zucchini, and squash. Hajizadeh-Sharafabad F, Tarighat-Esfanjani A, Ghoreishi Z, Sarreshtedari M. Lutein supplementation combined with a low-calorie diet in middle-aged obese individuals: effects on anthropometric indices, body composition and metabolic parameters. The most researched benefit of lutein is related to eye health, but it has also been linked to heart health, improved cognitive function, and reduced risk of certain types of cancer. This article explores everything you need to know about lutein, including food sources of it, supplements, health benefits, and potential risks. What is lutein? Fruits and vegetables that are sources for lutein and zeaxanthin: the macular pigment in human eyes. A., de Vries, A. J., Goldbohm, R. A., Tijburg, L. B., Kardinaal, A. F., and van Poppel, G. Macular pigment density in relation to serum and adipose tissue concentrations of lutein and serum concentrations of zeaxanthin. Falsini, B., Piccardi, M., Iarossi, G., Fadda, A., Merendino, E., and Valentini, P. Influence of short-term antioxidant supplementation on macular function in age-related maculopathy: a pilot study including electrophysiologic assessment. Nutrition 2003;19(3):244-249. Ophthalmology 2003;110(1):51-60. Parenteral nutrition with branched-chain amino acids in hepatic encephalopathy. Arch.Biochem.Biophys. View abstract. Some evidence shows that people who obtain more lutein from their diets experience lower rates of breast, colon, cervical and lung cancers. Lyle, B. J., Mares-Perlman, J. Zhang Y, Knol LL, Tan L. Association between dietary lutein/zeaxanthin intake and metabolic syndrome among US females: An analysis of national health and examination surveys 2015-2018. When taken in high doses, potential lutein side effects can includeharmless yellowing of the skin called carotenemia or vomiting, although these are rare. View abstract. 7-15-2001;391(2):160-164. Liver Cleanse | Lutein Benefits, Uses, Foods, Side Effects and More - Dr Our team aims to be not only thorough with its research, but also objective and unbiased. View abstract. Clin Nutr 2016;35(1):109-16. Optometry 2004;75:216-30. View abstract. View abstract. We currently have no information for LUTEIN overview. 2012;25(5):523-527. View abstract. View abstract. Epidemiology 2004;15(6):738-745. helping reduce eye fatigue, glare and light sensitivity, helping keep the lens and retina at appropriate densities. Berson EL, Rosner B, Sandberg MA, et al. View abstract. A. Serum carotenoids and alpha-tocopherol and risk of nonmelanoma skin cancer. It seems that people with this disorder might not absorb some carotenoids from food very well and often show low blood levels of lutein. Am J Clin Nutr 2004;79 1045-52. View abstract. View abstract. Thyagarajan, B., Meyer, A., Smith, L. J., Beckett, W. S., Williams, O. D., Gross, M. D., and Jacobs, D. R., Jr. Serum carotenoid concentrations predict lung function evolution in young adults: the Coronary Artery Risk Development in Young Adults (CARDIA) study. 2008;49(8):3328-3335. View abstract. Exp.Eye Res. View abstract. Double-masked, placebo-controlled, randomized trial of lutein and antioxidant supplementation in the intervention of atrophic age-related macular degermation: the Veterans LAST study (Lutein Antioxidant Supplement Trial). However, at this time, more research is still needed to help us fully understand the effects of carotenoids on cancer, along with immune, hormonal and cardiovascular health, independent of other nutrients that are found in fruits and vegetables. Zhao, X., Aldini, G., Johnson, E. J., Rasmussen, H., Kraemer, K., Woolf, H., Musaeus, N., Krinsky, N. I., Russell, R. M., and Yeum, K. J. SanGiovanni, J. P. and Neuringer, M. The putative role of lutein and zeaxanthin as protective agents against age-related macular degeneration: promise of molecular genetics for guiding mechanistic and translational research in the field. Melatonin: 2 people, 18.18%. Snellen, E. L., Verbeek, A. L., Van Den Hoogen, G. W., Cruysberg, J. R., and Hoyng, C. B. Neovascular age-related macular degeneration and its relationship to antioxidant intake. 2006;124(8):1151-1162. Circulation 6-19-2001;103(24):2922-2927. J Nutr 1999;129(12):2162-2169. 2012;32(6):418-424. View abstract. PLoS One 2019;14(12):e0227048. J Nutr 1997;127:1636S-45S. Li, L., Chen, C. Y., Aldini, G., Johnson, E. J., Rasmussen, H., Yoshida, Y., Niki, E., Blumberg, J. Arch Neurol 2000;57:956-63. Clin Cosmet Investig Dermatol 2016;9:325-332. 2011;52(12):9207-9217. Spraycar M, ed. View abstract. Dietary lutein and cognitive function in adults: A meta-analysis of randomized controlled trials. Dani, C., Lori, I., Favelli, F., Frosini, S., Messner, H., Wanker, P., De, Marini S., Oretti, C., Boldrini, A., Massimiliano, C., Bragetti, P., and Germini, C. Lutein and zeaxanthin supplementation in preterm infants to prevent retinopathy of prematurity: a randomized controlled study. Invest Ophthalmol.Vis.Sci. View abstract. Hininger, I. Ren YB, Qi YX, Su XJ, Luan HQ, Sun Q. Cardinault, N., Gorrand, J. M., Tyssandier, V., Grolier, P., Rock, E., and Borel, P. Short-term supplementation with lutein affects biomarkers of lutein status similarly in young and elderly subjects. View abstract. J.Nutr. 2004;3(6):310-316. View abstract. Relationship of serum alpha-tocopherol, carotenoids and retinol with the risk of breast cancer. Plasma kinetics of lutein, zeaxanthin, and 3-dehydro-lutein after multiple oral doses of a lutein supplement. Cancer Sci. The effects of lutein and zeaxanthin supplementation on cognitive function in adults with self-reported mild cognitive complaints: A randomized, double-blind, placebo-controlled study. The risk of vision loss decreased by 19%. . Br.J.Ophthalmol. Eur.J.Clin.Nutr. J Natl.Cancer Inst. Lutein is a carotenoid with reported anti-inflammatory properties. View abstract. Compared to the control group, diabetic rats taking the supplements experienced lower oxidative stress rates and less damage done to the retina of the eyes, despite being under hyperglycemic conditions. J Nutr 2003;133(1):98-101. Tan, J. S., Wang, J. J., Flood, V., Rochtchina, E., Smith, W., and Mitchell, P. Dietary antioxidants and the long-term incidence of age-related macular degeneration: the Blue Mountains Eye Study. 1996;126(9):2098-2106. Lutein, zeaxanthin, macular pigment, and visual function in adult cystic fibrosis patients. Leermakers ET, Darweesh SK, Baena CP, et al. Carotenoids and antioxidants in age-related maculopathy italian study: multifocal electroretinogram modifications after 1 year. Cho E, Seddon JM, Rosner B, et al. Exp.Gerontol. 2007;78(5):213-219. View abstract. Yamini, S., West, K. P., Jr., Wu, L., Dreyfuss, M. L., Yang, D. X., and Khatry, S. K. Circulating levels of retinol, tocopherol and carotenoid in Nepali pregnant and postpartum women following long-term beta-carotene and vitamin A supplementation. Flood V, Smith W, Wang JJ, et al. 2006;47(12):5227-5233. 2014 May;174(5):763-71. J Epidemiol Community Health 1998;52:468-72. Prospective study of lutein/zeaxanthin intake and risk of age-related macular degeneration. Hammond, B. R., Jr., Curran-Celentano, J., Judd, S., Fuld, K., Krinsky, N. I., Wooten, B. R., and Snodderly, D. M. Sex differences in macular pigment optical density: relation to plasma carotenoid concentrations and dietary patterns. What are the precautions when taking this product? View abstract. Researchers at Harvard University have found that supplementing with lutein daily can lower the risk for macular degeneration. Some animal studies show evidence that lutein offers significant protection against light-induced skin damage, such as signs of aging and potentially skin cancer. In the process, antioxidants like lutein protect healthy cells while halting the growth of malignant cells. Associations between age-related nuclear cataract and lutein and zeaxanthin in the diet and serum in the Carotenoids in the Age-Related Eye Disease Study, an Ancillary Study of the Women's Health Initiative. View abstract. A randomized trial of vitamin A and vitamin E supplementation for retinitis pigmentosa. Found that supplementing with lutein daily can lower the risk of urothelial cell carcinoma in the process, antioxidants lutein! Ua, Sperduto R, et al colon cancer: an assessment specific. 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