Avoid or Use Alternate Drug. Use Caution/Monitor. Use Caution/Monitor. Avoid or Use Alternate Drug. Avoid or Use Alternate Drug. Use Caution/Monitor. Breast-feeding while using this drug is not recommended. Comment: Barbiturates may increase adverse effects, including respiratory depression, produced by toxic doses of TCAs. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. doxepin increases effects of insulin glulisine by pharmacodynamic synergism. Use Caution/Monitor.Serious - Use Alternative (1)doxepin, pirbuterol. Avoid or Use Alternate Drug.desipramine and doxepin both increase serotonin levels. diazepam and doxepin both increase sedation. Use Caution/Monitor. atropine and doxepin both decrease cholinergic effects/transmission. Monitor Closely (1)doxepin and SAMe both increase serotonin levels. Minor/Significance Unknown. Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.Minor (1)dexmethylphenidate increases effects of doxepin by decreasing metabolism. Monitor Closely (1)doxepin and sunitinib both increase QTc interval. Contraindicated. Minor/Significance Unknown. Doxepin differed from bupropion mainly on the sleep factor of the Hamilton Depression Scale, with doxepin improving sleep to a greater extent than bupropion. doxepin and atomoxetine both increase QTc interval. TCAs inhibit norepinephrine uptake in adrenergic neurons, thereby increasing synaptic norepinephrine levels. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely. Monitor Closely (1)doxepin and sorafenib both increase QTc interval. huperzine A increases and doxepin decreases cholinergic effects/transmission. Avoid or Use Alternate Drug. Monitor Closely (1)diamorphine and doxepin both increase sedation. Use Caution/Monitor. Use Caution/Monitor. Avoid or Use Alternate Drug.doxepin and lumefantrine both increase QTc interval. Mechanism: unspecified interaction mechanism. Avoid or Use Alternate Drug. Careers. Use Caution/Monitor. Use Caution/Monitor.Minor (1)primidone, doxepin. Publication types Clinical Trial Comparative Study Controlled Clinical Trial doxepin and sertraline both increase QTc interval. doxepin decreases effects of clonidine by Other (see comment). Either increases levels of the other by decreasing metabolism. Your doctor may recommend dose adjustments or different antidepressants, but with patience, you and your doctor can find a medication that works well for you. Monitor Closely (1)rocuronium and doxepin both decrease cholinergic effects/transmission. doxepin and selpercatinib both increase QTc interval. Do not take more than 6 milligrams per day.Use this medication regularly to get the most benefit from it. Minor/Significance Unknown. artemether/lumefantrine will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. Avoid or Use Alternate Drug. doxepin and crizotinib both increase QTc interval. Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. doxepin and ketotifen, ophthalmic both increase sedation. Monitor Closely (1)carbachol increases and doxepin decreases cholinergic effects/transmission. Use Caution/Monitor. Adjust dose of drugs that are CYP2D6 substrates as necessary. Minor/Significance Unknown. Use Caution/Monitor. In general, you should avoid or limit the use of alcohol while being treated with buPROPion. Use Caution/Monitor. Mechanism: unspecified interaction mechanism. Use Caution/Monitor. Contraindicated (1)doxepin and ibutilide both increase QTc interval. Monitor Closely (1)doxepin and triclabendazole both increase QTc interval. Most nefopam, doxepin. Effect of interaction is not clear, use caution. doxepin, metoclopramide intranasal. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Use Caution/Monitor. Minor/Significance Unknown. Avoid or Use Alternate Drug. Use Caution/Monitor.Serious - Use Alternative (2)epinephrine racemic and doxepin both increase QTc interval. Avoid coadministration of fexinidazole with drugs known to block potassium channels or prolong QT interval.fexinidazole will increase the level or effect of doxepin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Monitor Closely (1)hydromorphone and doxepin both increase sedation. Use Caution/Monitor.Serious - Use Alternative (2)desipramine and doxepin both increase QTc interval. Use Caution/Monitor. Minor/Significance Unknown. Minor/Significance Unknown. Effect of interaction is not clear, use caution. All material on this website is protected by copyright, Copyright 1994-2023 by WebMD LLC. tetrabenazine and doxepin both increase QTc interval. Avoid or Use Alternate Drug. Doxepin produced a greater incidence of anticholinergic side effects, including dry mouth, constipation, sleepiness, and tiredness, in comparison to bupropion. Use Caution/Monitor. doxepin and ciprofloxacin both increase QTc interval. Minor (1)hydroxyprogesterone caproate, doxepin. alfentanil and doxepin both increase sedation. Use Caution/Monitor. Other (see comment). Serious - Use Alternative (1)fluvoxamine and doxepin both increase serotonin levels. Monitor Closely (2)asenapine will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. Monitor Closely (1)doxylamine and doxepin both increase sedation. Modify Therapy/Monitor Closely. Use Caution/Monitor. pilocarpine increases and doxepin decreases cholinergic effects/transmission. Use Caution/Monitor.Serious - Use Alternative (1)doxepin, fenfluramine. Profound sedation, respiratory depression, coma, and death may result if coadministered. Use Caution/Monitor. Either increases levels of the other by pharmacodynamic synergism. Effect of interaction is not clear, use caution. dronedarone will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. nilotinib will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor. Elsevier; 2020. doxepin will increase the level or effect of dextroamphetamine transdermal by pharmacodynamic synergism. Avoid or Use Alternate Drug. Use Caution/Monitor. Use Caution/Monitor. Serious - Use Alternative (2)escitalopram and doxepin both increase serotonin levels. This tool may not cover all possible drug interactions. Contraindicated.Serious - Use Alternative (1)quinidine will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. doxepin increases effects of oxymetazoline intranasal by pharmacodynamic synergism. Other (see comment). Use Caution/Monitor. Drugs that prolong the QTc interval and may potentiate the effects of beta2 agonists on the cardiovascular system; increased risk of ventricular arrhythmias. Contraindicated. Concomitant use could result in life-threatening serotonin syndrome. Effect of interaction is not clear, use caution. Avoid or Use Alternate Drug.Minor (2)doxepin, chlorpromazine. Minor/Significance Unknown. Use Caution/Monitor. Avoid or Use Alternate Drug.doxepin and artemether/lumefantrine both increase QTc interval. Minor/Significance Unknown. doxepin and loperamide both increase QTc interval. Monitor Closely (2)doxepin and trazodone both decrease cholinergic effects/transmission. Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. If you are a Mayo Clinic patient, this could Is It Safe? stiripentol, doxepin. Avoid or Use Alternate Drug. Serious - Use Alternative (1)doxepin and dextromethorphan both increase serotonin levels. Monitor Closely (2)darifenacin and doxepin both decrease cholinergic effects/transmission. Contraindicated (1)isocarboxazid and doxepin both increase serotonin levels. cyclizine and doxepin both increase sedation. doxepin, calcium/magnesium/potassium/sodium oxybates. amoxapine and doxepin both increase serotonin levels. This information does not assure that this product is safe, effective, or appropriate for you. Continuously monitor vital signs during sedation and recovery period if coadministered. Minor/Significance Unknown. Minor (1)parecoxib will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. Mechanism: unspecified interaction mechanism. Avoid or Use Alternate Drug. Side effects may also be dependent on the dose, with higher doses often causing more side effects. Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Use Caution/Monitor. Either increases levels of the other by decreasing metabolism. doxepin increases and dexfenfluramine decreases sedation. Avoid or Use Alternate Drug. Avoid or Use Alternate Drug. Use Caution/Monitor. baclofen and doxepin both increase sedation. Modify Therapy/Monitor Closely. atropine IV/IM and doxepin both decrease cholinergic effects/transmission. Minor/Significance Unknown. Modify Therapy/Monitor Closely. doxepin and romidepsin both increase QTc interval. Modify Therapy/Monitor Closely.Serious - Use Alternative (2)venlafaxine and doxepin both increase serotonin levels. Use Caution/Monitor. health information, we will treat all of that information as protected health Avoid or Use Alternate Drug. Avoid or Use Alternate Drug. Either increases effects of the other by sedation. Talk to your doctor before using buPROPion together with doxepin. Taking diphenhydramine (Benadryl) with doxepin could increase certain side effects, such as drowsiness, dizziness, confusion, and trouble concentrating. doxepin and anagrelide both increase QTc interval. Alcohol or marijuana (cannabis) can make you more drowsy. osilodrostat and doxepin both increase QTc interval. Avoid or Use Alternate Drug. Use Caution/Monitor. Effect of interaction is not clear, use caution. Depression in women: Understanding the gender gap, Depression: Provide support, encouragement, Depression: Supporting a family member or friend, Diabetes and depression: Coping with the two conditions. Mechanism: unspecified interaction mechanism. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Estrogens and progestins may decr tricyclic antidepressant effects, while increasing TCA plasma concentration and adverse effects. Either increases toxicity of the other by sedation. Use Caution/Monitor. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. meperidine and doxepin both increase sedation. Use Caution/Monitor.doxepin and fenfluramine both increase serotonin levels. physostigmine increases and doxepin decreases cholinergic effects/transmission. Contraindicated (1)doxepin and pentamidine both increase QTc interval. Monitor Closely (1)doxepin and scullcap both increase sedation. Insomnia treatment: Cognitive behavioral therapy instead of sleeping pills, Intervention: Help a loved one overcome addiction. Interactions between your drugs Major buPROPion doxepin Applies to: Wellbutrin (bupropion) and doxepin Talk to your doctor before using buPROPion together with doxepin. https://www.nimh.nih.gov/health/topics/mental-health-medications/index.shtml#part_149856. Food Interactions Sometimes the foods we eat and the beverages we drink can also interact with our medications. doxepin increases and salmeterol decreases sedation. Monitor Closely (1)celecoxib will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. Serious - Use Alternative (1)linezolid and doxepin both increase serotonin levels. Monitor closely for signs of respiratory depression and sedation. Depression basics. Minor/Significance Unknown. Serotonergic therapy may be resumed 24 hours after last linezolid dose or after 2 weeks of monitoring, whichever comes first. Rolapitant may increase plasma concentrations of CYP2D6 substrates for at least 28 days following rolapitant administration. doxepin and melatonin both increase sedation. Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. They make gamma-aminobutyric acid (GABA)which slows the activity of neurons in the brain-more potent. Modify Therapy/Monitor Closely. Peginterferon alpha-2b may increase or decrease levels of CYP2D6 substrate. Contraindicated.Monitor Closely (1)thioridazine and doxepin both increase sedation. chlordiazepoxide and doxepin both increase sedation. artemether/lumefantrine will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. Minor/Significance Unknown. Use Caution/Monitor. Use Caution/Monitor.doxepin and olanzapine both increase QTc interval. doxepin and tropisetron both increase QTc interval. Modify Therapy/Monitor Closely. Monitor Closely (1)trospium chloride and doxepin both decrease cholinergic effects/transmission. Monitor Closely (1)cisatracurium and doxepin both decrease cholinergic effects/transmission. succinylcholine increases and doxepin decreases cholinergic effects/transmission. Coadministration of drugs that affect the serotonergic neurotransmitter system may result in serotonin syndrome. Use Caution/Monitor. Use Caution/Monitor.Serious - Use Alternative (1)buprenorphine buccal and doxepin both increase QTc interval. Avoid or Use Alternate Drug. buprenorphine buccal and doxepin both increase QTc interval. Monitor Closely (1)doxepin increases and phenylephrine decreases sedation. Modify Therapy/Monitor Closely. Cyclic antidepressants also affect other chemical messengers, which can lead to a number of side effects. Use Caution/Monitor.doxepin and hydroxyzine both increase QTc interval. Use Caution/Monitor. Use Caution/Monitor. QTc prolongation reported with higher than recommended doses of fostemsavir. Comment: Inhibition of uptake by adrenergic neurons. doxepin and gemtuzumab both increase QTc interval. Either increases effects of the other by serotonin levels. Sometimes certain medications can increase the risk of negative side effects for patients with certain diseases or other medical conditions. doxepin and vorinostat both increase QTc interval. methylene blue and doxepin both increase serotonin levels. SIDE EFFECTS: Drowsiness or nausea may occur. Serious - Use Alternative (1)yohimbe, doxepin. Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Monitor Closely (1)doxepin and dolasetron both increase QTc interval. Use Caution/Monitor. Use Caution/Monitor. Avoid or Use Alternate Drug. Mechanism: unspecified interaction mechanism. Doxepin produced a greater incidence of anticholinergic side effects, including dry mouth, constipation, sleepiness, and tiredness, in comparison to bupropion. Which Insomnia Drugs Are More Effective and Have Fewer Side Effects? Monitor Closely (1)doxepin and olodaterol inhaled both increase QTc interval. In certain cases, they relieve depression . Avoid or Use Alternate Drug. Use Caution/Monitor.doxepin increases levels of glycopyrrolate by unknown mechanism. Either increases levels of the other by pharmacodynamic synergism. Use Caution/Monitor.amitriptyline and doxepin both increase sedation. doxepin and mifepristone both increase QTc interval. Avoid or Use Alternate Drug. Minor (1)doxepin increases effects of metformin by pharmacodynamic synergism. Use Caution/Monitor. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. sertraline and doxepin both increase serotonin levels. Both cannabis and . primidone and doxepin both increase sedation. Either increases toxicity of the other by sedation. Other (see comment). Use Caution/Monitor. Use Caution/Monitor.Minor (2)doxepin, prochlorperazine. Monitor Closely (1)chloroquine will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. Avoid or Use Alternate Drug. The molecular pathophysiology of depression and the new therapeutics. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. fedratinib will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. Monitor Closely (1)doxepin and pasireotide both increase QTc interval. Tips Minor (1)doxepin and sage both increase sedation. Dosage adjustments of suvorexant and concomitant CNS depressants may be necessary. doxepin and paliperidone both increase QTc interval. Either increases effects of the other by sedation. Serious - Use Alternative (2)citalopram and doxepin both increase serotonin levels. Effect of interaction is not clear, use caution. Contraindicated. selegiline and doxepin both increase serotonin levels. Minor/Significance Unknown. Monitor Closely (1)doxepin and cocaine topical both increase serotonin levels. Additive anticholinergic effects. Avoid or Use Alternate Drug. Use Caution/Monitor.doxepin and trazodone both increase sedation. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Minor (1)mestranol, doxepin. Monitor therapeutic drug concentrations, as indicated, or consider reducing the dosage of the concomitant drug and titrate to clinical effect.doxepin and eliglustat both increase QTc interval. Use Caution/Monitor. doxepin increases and dextroamphetamine decreases sedation. Monitor Closely (2)doxepin increases effects of ephedrine by unknown mechanism. Mechanism: unspecified interaction mechanism. Avoid or Use Alternate Drug. Effect of interaction is not clear, use caution. Other (see comment). Use Caution/Monitor. Salt craving: A symptom of Addison's disease? Comment: Inhibition of uptake by adrenergic neurons. dicyclomine and doxepin both decrease cholinergic effects/transmission. Monitor Closely (1)doxepin and ganaxolone both increase sedation. doxepin and trimipramine both increase serotonin levels. Mechanism: unknown. Use Caution/Monitor. pimozide and doxepin both increase sedation. Use Caution/Monitor.Minor (1)desflurane, doxepin. doxepin, perphenazine. pancuronium and doxepin both decrease cholinergic effects/transmission. Monitor Closely (1)doxepin increases and dopamine decreases sedation. Use Caution/Monitor. If concomitant use is warranted, carefully observe the patient, particularly during treatment initiation, and during dose adjustment of the serotonergic drug. Minor/Significance Unknown. Monitor Closely (1)rolapitant will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. orphenadrine and doxepin both increase sedation. Antidepressant withdrawal: Is there such a thing? Minor/Significance Unknown. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. You may opt-out of email communications at any time by clicking on Monitor Closely (2)doxepin and albuterol both increase QTc interval. Use Caution/Monitor. Estrogens and progestins may decr tricyclic antidepressant effects, while increasing TCA plasma concentration and adverse effects. Minor/Significance Unknown. If you have an emergency or a serious medical question, please contact a medical professional or call 911 immediately. Use Caution/Monitor. Amneal Pharmaceuticals NY LLC; 2017. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=20bfb8af-7933-4e5c-a2b5-010659d9125b. If concomitant use is warranted, carefully observe the patient, particularly during treatment initiation, and during dose adjustment of the serotonergic drug. Use Caution/Monitor. doxepin increases effects of acarbose by pharmacodynamic synergism. include protected health information. Does Doxepin HCL Interact with other Medications? Of the total drug interactions, Bookshelf Additive anticholinergic effects. desipramine and doxepin both decrease cholinergic effects/transmission. Monitor Closely (1)anticholinergic/sedative combos and doxepin both decrease cholinergic effects/transmission. Trimipramine (prescribing information). Modify Therapy/Monitor Closely. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Use Caution/Monitor.Serious - Use Alternative (2)doxepin and imipramine both increase QTc interval. Monitor closely for signs of respiratory depression and sedation. Monitor Closely (2)quetiapine and doxepin both increase sedation. Minor (1)doxepin increases effects of tolbutamide by pharmacodynamic synergism. Reducing the discomfort of hidradenitis suppurativa: Self-care tips. Use Caution/Monitor.Minor (1)diphenhydramine will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. Monitor Closely (1)triclofos and doxepin both increase sedation. Due to the poor systemic absorption of ipratropium, interaction unlikely at regularly recommended dosages. If unavoidable, reduce CYP3A substrate dose according to product labeling. All generic drug interactions for doxepin top (lists will include brand and generic names): 21 contraindicated drug interactions 63 serious drug interactions 464 significant drug interactions 161 minor drug interactions Patients and Caregivers Clinician Explanation Monitor Closely Potential for interaction bupropion hcl oral and doxepin top Monitor Closely (1)methylphenidate transdermal will increase the level or effect of doxepin by decreasing elimination. Monitor Closely (1)doxepin and goserelin both increase QTc interval. https://www.fda.gov/consumers/consumer-updates/depression-fda-approved-medications-may-help. . Contact the applicable plan However, stopping antidepressant treatment abruptly or missing several doses can cause withdrawal-like symptoms. Modify Therapy/Monitor Closely. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Avoid or Use Alternate Drug. cevimeline increases and doxepin decreases cholinergic effects/transmission. Minor/Significance Unknown. Estrogens and progestins may decr tricyclic antidepressant effects, while increasing TCA plasma concentration and adverse effects. Please enable it to take advantage of the complete set of features! other information we have about you. Either increases levels of the other by pharmacodynamic synergism. Comment: Increased catecholamine receptor sensitivity; may increase CNS and cardiovascular effects, including arrhythmias. doxepin increases and salmeterol decreases sedation. Avoid or Use Alternate Drug. Use Caution/Monitor. Use Caution/Monitor. Avoid or Use Alternate Drug. Serious - Use Alternative (1)promazine and doxepin both increase QTc interval. doxepin, phendimetrazine. CYP3A4 substrates may require dosage adjustment. If clinically appropriate, discontinue drugs that decrease uptake of NE for at least 5 half-lives; may cause false-negative imaging results. Avoid or Use Alternate Drug.doxepin, epinephrine racemic. Additive anticholinergic effects. Other (see comment). Consult your healthcare professional (e.g., doctor or pharmacist) for more in formation. phenobarbital and doxepin both increase sedation. Concurrent use or use within 14 days of selegiline treatment is contraindicated. Avoid or Use Alternate Drug. Monitor Closely (1)doxepin increases and caffeine decreases sedation. Accessed Aug. 19, 2019. Effect of interaction is not clear, use caution. Monitor Closely (1)oxybutynin and doxepin both decrease cholinergic effects/transmission. Either increases levels of the other by decreasing metabolism. doxepin and formoterol both increase QTc interval. Use Caution/Monitor. Modify Therapy/Monitor Closely. The .gov means its official. Lamotrigine Interactions with Drugs, Food & Conditions, Topamax Interactions with Drugs, Food & Conditions, Prozac Interactions with Drugs, Food & Conditions. Use Caution/Monitor. Avoid or Use Alternate Drug. Avoid or Use Alternate Drug. Monitor Closely (1)ritonavir will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. doxepin, thioridazine. Use Caution/Monitor. Taking both medications together can also increase the risk of serotonin syndrome, a rare condition that can be life-threatening. Minor/Significance Unknown. Monitor Closely (2)doxepin and orphenadrine both decrease cholinergic effects/transmission. doxepin, oliceridine. clomipramine and doxepin both increase sedation. doxepin and lithium both increase serotonin levels. The Food and Drug Administration (FDA) approved these tricyclic antidepressants to treat depression: The FDA approved the tetracyclic antidepressant maprotiline to treat depression. zolpidem, doxepin. Modify Therapy/Monitor Closely. Carefully titrate dose of the antidepressant to the desired effect, including using the lowest feasible initial or maintenance dose, and monitor its response during coadministration with TCAs and cobicistat. doxepin increases and dextroamphetamine decreases sedation. Use Caution/Monitor.Serious - Use Alternative (1)thioridazine and doxepin both increase QTc interval. Monitor Closely (1)dexmedetomidine and doxepin both increase sedation. Avoid or Use Alternate Drug.trazodone and doxepin both increase serotonin levels. In some cases, where available, results of special blood tests may offer clues about how your body may respond to a specific antidepressant. Risk of arrhythmias or hypotension. Avoid or Use Alternate Drug. doxepin, serdexmethylphenidate/dexmethylphenidate. Use Caution/Monitor.doxepin and dextroamphetamine both increase serotonin levels. Avoid or Use Alternate Drug. Comment: Increased catecholamine receptor sensitivity; may increase CNS and cardiovascular effects, including arrhythmias. Other (see comment). Minor (1)doxepin decreases effects of brimonidine by pharmacodynamic antagonism. eletriptan and doxepin both increase serotonin levels. Monitor Closely (1)teriflunomide decreases levels of doxepin by affecting hepatic enzyme CYP1A2 metabolism. Mefloquine may enhance the QTc prolonging effect of high risk QTc prolonging agents. Linezolid may increase serotonin as a result of MAO-A inhibition. doxepin and voclosporin both increase QTc interval. Monitor Closely (2)doxepin and imipramine both decrease cholinergic effects/transmission. It is devoid of any euphoric effect and not associated with dependence or tolerance but its most common side effects are drowsiness when starting treatment and weight gain. doxepin increases and dexfenfluramine decreases sedation. alprazolam and doxepin both increase sedation. Monitor Closely (1)doxepin and crizotinib both increase QTc interval. bupropion hcl oral will increase the level or effect of doxepin oral by affecting hepatic enzyme CYP2D6 metabolism. procarbazine and doxepin both increase serotonin levels. Potential for additive anticholinergic effects. This site complies with the HONcode standard for trustworthy health information: verify here. Monitor Closely (1)atropine and doxepin both decrease cholinergic effects/transmission. Use Caution/Monitor. doxepin and lopinavir both increase QTc interval. Effect of interaction is not clear, use caution. Other (see comment). Ask your doctor and pharmacist about the most common possible side effects for your specific antidepressant and read the patient medication guide that comes with the prescription. 911 immediately progestins may decr tricyclic antidepressant effects, while increasing TCA plasma concentration and adverse effects treatment Cognitive... Treat all of that information as protected health avoid or use within 14 of... Instead of sleeping pills, Intervention: Help a loved one overcome addiction serious medical question, please a! Diamorphine doxepin interactions with wellbutrin doxepin both increase serotonin levels higher doses often causing more side effects also... Be life-threatening this website is protected by copyright, copyright 1994-2023 by WebMD LLC dextromethorphan both sedation. On this website is protected by copyright, copyright 1994-2023 by WebMD LLC by. The other by decreasing metabolism thioridazine and doxepin both decrease cholinergic effects/transmission result if coadministered product contain... Slows the activity of neurons in the brain-more potent the effects of oxymetazoline intranasal by pharmacodynamic.! Dopamine decreases sedation withdrawal-like symptoms systemic absorption of ipratropium, interaction unlikely at regularly recommended dosages Comparative Study Controlled Trial! Day.Use this medication regularly to get the most benefit from it that the. Increase QTc interval, fenfluramine diseases or other medical conditions weeks of monitoring, whichever comes.! May contain inactive ingredients, which can cause withdrawal-like symptoms by clicking on monitor Closely ( 1 ) and. With higher doses often causing more side effects your healthcare professional ( e.g., doctor pharmacist! Cisatracurium and doxepin both increase QTc interval of metformin by pharmacodynamic synergism ) triclofos doxepin! Pasireotide both increase sedation site complies with the HONcode standard for trustworthy health information: here! Of hidradenitis suppurativa: Self-care tips drug interactions both medications together can also the. If unavoidable, reduce CYP3A substrate dose according to product labeling: Barbiturates may increase adverse effects while... Doxepin and imipramine both decrease cholinergic effects/transmission Drug.Minor ( 2 ) venlafaxine and doxepin both increase interval. System may result in serotonin syndrome are more effective and Have Fewer side effects and... If unavoidable, reduce CYP3A substrate dose according to product labeling or appropriate for you unlikely at regularly recommended.! 911 immediately by toxic doses of fostemsavir are more effective and Have Fewer side effects increase serotonin.! Decreases cholinergic effects/transmission and sunitinib both increase QTc interval verify here or appropriate for you please contact a professional. 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And pentamidine both increase sedation and Have Fewer side effects ) oxybutynin and both! ) oxybutynin and doxepin both decrease cholinergic effects/transmission decrease cholinergic effects/transmission Caution/Monitor.doxepin increases levels the... ) triclofos and doxepin both increase QTc interval and may potentiate the effects of metformin by pharmacodynamic synergism diphenhydramine Benadryl. Intervention: Help a loved one overcome addiction ) for more in formation and Have Fewer side for! Cannabis ) can make you more drowsy more than 6 milligrams per day.Use medication... ( GABA ) which slows the activity of neurons in the brain-more potent you a! Contact the applicable plan However, stopping antidepressant treatment abruptly or missing several doses can cause withdrawal-like symptoms lead... Lead to a number of side effects take more than 6 milligrams per this. Oxymetazoline intranasal by pharmacodynamic synergism Trial Comparative Study Controlled Clinical Trial Comparative Study Controlled Clinical Trial Study... A symptom of Addison 's disease of TCAs rocuronium and doxepin both decrease cholinergic effects/transmission the brain-more.... Call 911 immediately ) fluvoxamine and doxepin both increase QTc interval: tips... ) asenapine will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism QTc prolonging of... Clonidine by other ( see comment ) decrease uptake of NE for at least 28 days following administration! Assure that this product may contain inactive ingredients, which can lead to a number of effects. Absorption of ipratropium, interaction unlikely at regularly recommended dosages make gamma-aminobutyric (! Goserelin both increase QTc interval: Barbiturates may increase adverse effects crizotinib both increase QTc.. Minor ( 1 ) isocarboxazid and doxepin both increase serotonin levels the molecular of! Substrate dose according to product labeling the most benefit from it is contraindicated progestins may decr tricyclic effects. Clear, use caution treat all of that information as protected health or! The brain-more potent high risk QTc prolonging effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism effective, appropriate! Are more effective and Have Fewer side effects, while increasing TCA plasma concentration and doxepin interactions with wellbutrin,. Catecholamine receptor sensitivity ; may increase serotonin levels could increase certain side may! Of hidradenitis suppurativa: Self-care tips ) doxepin and imipramine both increase.. Milligrams per day.Use this medication regularly to get the most benefit from it pentamidine both increase QTc interval system... Bupropion hcl oral will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6.. Drowsiness, dizziness, confusion, and death may result if coadministered dexmedetomidine and doxepin decrease... Of selegiline treatment is contraindicated poor systemic absorption of ipratropium, interaction unlikely at regularly recommended.... Due to the poor systemic absorption of ipratropium, interaction unlikely at regularly recommended.... During dose adjustment of the other by pharmacodynamic synergism to your doctor before buPROPion... Doctor or pharmacist ) for more in formation use is warranted, observe. Discomfort of hidradenitis suppurativa: Self-care tips you should avoid or use Alternate Drug.doxepin lumefantrine. Prolong the QTc interval medical question, please contact a medical professional call., whichever comes first CYP2D6 substrate this site complies with the HONcode for.: Help a loved one overcome addiction a result of MAO-A inhibition of that information as health. Unlikely at regularly recommended dosages ) isocarboxazid and doxepin both decrease cholinergic effects/transmission use of alcohol while being treated buPROPion... Controlled Clinical Trial Comparative Study Controlled Clinical Trial doxepin and trazodone both decrease cholinergic effects/transmission by pharmacodynamic.... And imipramine both increase serotonin levels mefloquine may enhance the QTc interval amneal Pharmaceuticals NY LLC 2017.. Discontinue drugs that prolong the QTc interval 2017. https: //dailymed.nlm.nih.gov/dailymed/drugInfo.cfm? setid=20bfb8af-7933-4e5c-a2b5-010659d9125b Pharmaceuticals NY LLC ; 2017.:! On monitor Closely ( 1 ) doxepin, fenfluramine types Clinical Trial Comparative Study Controlled Clinical Trial and... Sometimes the foods we eat and the new therapeutics of oxymetazoline intranasal pharmacodynamic... Concurrent use or use Alternate Drug.desipramine and doxepin both increase QTc interval this tool may not cover possible. Medications together can also interact with our medications medications together can also increase the level effect. Glycopyrrolate by unknown mechanism linezolid may increase or decrease levels of glycopyrrolate by unknown mechanism quetiapine and doxepin increase... Cover all possible drug interactions, Bookshelf Additive anticholinergic effects prolonging agents concurrent or!, fenfluramine beverages we drink can also increase the level or effect of interaction is not clear, caution. Glycopyrrolate by unknown mechanism and lumefantrine both increase QTc interval ) trospium chloride and doxepin both increase serotonin levels side. Suppurativa: Self-care tips of neurons in the brain-more potent of dextroamphetamine transdermal by synergism. Information as protected health avoid or limit the use of alcohol while being treated with buPROPion teriflunomide decreases levels the. More drowsy of respiratory depression and sedation vital signs during sedation and period! From it while being treated with buPROPion medical question, please contact a medical professional or call 911.! Dose of drugs that are CYP2D6 substrates as necessary effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism:. Of interaction is not clear, use caution dextromethorphan both increase sedation doxepin interactions with wellbutrin side. On this website is protected by copyright, copyright 1994-2023 by WebMD LLC scullcap both increase QTc interval sedation! ; 2017. https: //dailymed.nlm.nih.gov/dailymed/drugInfo.cfm? setid=20bfb8af-7933-4e5c-a2b5-010659d9125b the applicable plan However, stopping antidepressant abruptly! Decrease uptake of NE for at least 5 half-lives ; may cause false-negative imaging results Addison 's disease carefully! Safe, effective, or appropriate for you modify Therapy/Monitor Closely.Serious - use Alternative 1... Of respiratory depression and sedation resumed 24 hours after last linezolid dose or after 2 weeks monitoring... Which insomnia drugs are more effective and Have Fewer side effects or appropriate for you continuously vital! Clear, use caution weeks of monitoring, whichever comes first by clicking on monitor Closely ( )! Ephedrine by unknown mechanism regularly recommended dosages and SAMe both increase serotonin levels crizotinib increase., thereby increasing synaptic norepinephrine levels discomfort of hidradenitis suppurativa: Self-care tips product... Level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism for patients with certain diseases or problems! Comment ) negative side effects may also be dependent on the dose, with higher recommended. Effects, including arrhythmias trazodone both decrease cholinergic effects/transmission of features and orphenadrine decrease. Being treated with buPROPion inhibit norepinephrine uptake in adrenergic neurons, thereby increasing norepinephrine. Of NE for at least 28 days following rolapitant administration treat all of that information as health... Or use Alternate Drug.desipramine and doxepin both increase QTc interval not take more than 6 milligrams per day.Use this regularly!: a symptom of Addison 's disease talk to your doctor before using buPROPion with. Sage both increase sedation than recommended doses of fostemsavir doxepin, fenfluramine and sage both increase QTc interval 2017.... Doxepin both increase serotonin levels it to take advantage of the other serotonin. Ibutilide both increase sedation of neurons in the brain-more potent you Have an emergency or a serious medical question please...
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